nonlinear regression (curve fit) dose-response function graphpad prism 9 Search Results


odyssey  (LI-COR)
99
LI-COR odyssey
Odyssey, supplied by LI-COR, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/nonlinear+regression+%28curve+fit%29+dose-response+function+graphpad+prism+9/custom%40Odyssey%4038084912?v=LI-COR
Average 99 stars, based on 1 article reviews
odyssey - by Bioz Stars, 2026-08
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odyssey imaging system  (LI-COR)
99
LI-COR odyssey imaging system
Odyssey Imaging System, supplied by LI-COR, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/nonlinear+regression+%28curve+fit%29+dose-response+function+graphpad+prism+9/custom%40odyssey-imaging-system%4038084912?v=LI-COR
Average 99 stars, based on 1 article reviews
odyssey imaging system - by Bioz Stars, 2026-08
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small molecule inhibitors  (Selleck Chemicals)
93
Selleck Chemicals small molecule inhibitors
Figure 2. High-throughput drug screen reveals cooperative induction of cell death by combined EGFR and FGFR inhibition in FGFR2 fusion+ ICC models. A. Schematic of high-throughput combination drug screen (Created with BioRender.com). The cell lines screened were: FGFR2-fusion+ ICC (ICC10/ICC10-6/ICC11/ICC13-7), FGFR2-fusion- ICC (ICC10-8/CCLP-1), FGFR2 amplified GC (KATO III/SNU-16). B. Screen results for the four FGFR2-fusion+ ICC cell lines tested. The chart shows the cooperative induction of cell death across the 111 drugs screened in combination with infigratinib 100 nM (upper panel), or futibatinib 40 nM (bottom panel), based on second highest single agent (HSA) score. <t>Inhibitors</t> of WT EGFR/ERBB signaling are highlighted red. The mutant selective EGFR inhibitor, CO1686 (Rociletinib) is highlighted black. Other inhibitors are color coded grey. C and D. Heat map and hierarchical cluster analysis generated in Morpheus (https://software.broadinstitute.org/morpheus/) based on second HSA score with infigratinib (C) and futibatinib (D) for cell death across all cell lines screened (color scheme is based on the minimum and maximum HSA values in each row). The top ranked combinations are presented as blown-up images on the right.
Small Molecule Inhibitors, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/nonlinear+regression+%28curve+fit%29+dose-response+function+graphpad+prism+9/pm35420673-254-13-19?v=Selleck+Chemicals
Average 93 stars, based on 1 article reviews
small molecule inhibitors - by Bioz Stars, 2026-08
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minitab 19 for windows  (Minitab Inc)
86
Minitab Inc minitab 19 for windows
Figure 2. High-throughput drug screen reveals cooperative induction of cell death by combined EGFR and FGFR inhibition in FGFR2 fusion+ ICC models. A. Schematic of high-throughput combination drug screen (Created with BioRender.com). The cell lines screened were: FGFR2-fusion+ ICC (ICC10/ICC10-6/ICC11/ICC13-7), FGFR2-fusion- ICC (ICC10-8/CCLP-1), FGFR2 amplified GC (KATO III/SNU-16). B. Screen results for the four FGFR2-fusion+ ICC cell lines tested. The chart shows the cooperative induction of cell death across the 111 drugs screened in combination with infigratinib 100 nM (upper panel), or futibatinib 40 nM (bottom panel), based on second highest single agent (HSA) score. <t>Inhibitors</t> of WT EGFR/ERBB signaling are highlighted red. The mutant selective EGFR inhibitor, CO1686 (Rociletinib) is highlighted black. Other inhibitors are color coded grey. C and D. Heat map and hierarchical cluster analysis generated in Morpheus (https://software.broadinstitute.org/morpheus/) based on second HSA score with infigratinib (C) and futibatinib (D) for cell death across all cell lines screened (color scheme is based on the minimum and maximum HSA values in each row). The top ranked combinations are presented as blown-up images on the right.
Minitab 19 For Windows, supplied by Minitab Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/nonlinear+regression+%28curve+fit%29+dose-response+function+graphpad+prism+9/10__1111_slash_ijfs__16652-89-4-4?v=Minitab+Inc
Average 86 stars, based on 1 article reviews
minitab 19 for windows - by Bioz Stars, 2026-08
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Image Search Results


Figure 2. High-throughput drug screen reveals cooperative induction of cell death by combined EGFR and FGFR inhibition in FGFR2 fusion+ ICC models. A. Schematic of high-throughput combination drug screen (Created with BioRender.com). The cell lines screened were: FGFR2-fusion+ ICC (ICC10/ICC10-6/ICC11/ICC13-7), FGFR2-fusion- ICC (ICC10-8/CCLP-1), FGFR2 amplified GC (KATO III/SNU-16). B. Screen results for the four FGFR2-fusion+ ICC cell lines tested. The chart shows the cooperative induction of cell death across the 111 drugs screened in combination with infigratinib 100 nM (upper panel), or futibatinib 40 nM (bottom panel), based on second highest single agent (HSA) score. Inhibitors of WT EGFR/ERBB signaling are highlighted red. The mutant selective EGFR inhibitor, CO1686 (Rociletinib) is highlighted black. Other inhibitors are color coded grey. C and D. Heat map and hierarchical cluster analysis generated in Morpheus (https://software.broadinstitute.org/morpheus/) based on second HSA score with infigratinib (C) and futibatinib (D) for cell death across all cell lines screened (color scheme is based on the minimum and maximum HSA values in each row). The top ranked combinations are presented as blown-up images on the right.

Journal: Cancer discovery

Article Title: EGFR Inhibition Potentiates FGFR Inhibitor Therapy and Overcomes Resistance in FGFR2 Fusion-Positive Cholangiocarcinoma.

doi: 10.1158/2159-8290.CD-21-1168

Figure Lengend Snippet: Figure 2. High-throughput drug screen reveals cooperative induction of cell death by combined EGFR and FGFR inhibition in FGFR2 fusion+ ICC models. A. Schematic of high-throughput combination drug screen (Created with BioRender.com). The cell lines screened were: FGFR2-fusion+ ICC (ICC10/ICC10-6/ICC11/ICC13-7), FGFR2-fusion- ICC (ICC10-8/CCLP-1), FGFR2 amplified GC (KATO III/SNU-16). B. Screen results for the four FGFR2-fusion+ ICC cell lines tested. The chart shows the cooperative induction of cell death across the 111 drugs screened in combination with infigratinib 100 nM (upper panel), or futibatinib 40 nM (bottom panel), based on second highest single agent (HSA) score. Inhibitors of WT EGFR/ERBB signaling are highlighted red. The mutant selective EGFR inhibitor, CO1686 (Rociletinib) is highlighted black. Other inhibitors are color coded grey. C and D. Heat map and hierarchical cluster analysis generated in Morpheus (https://software.broadinstitute.org/morpheus/) based on second HSA score with infigratinib (C) and futibatinib (D) for cell death across all cell lines screened (color scheme is based on the minimum and maximum HSA values in each row). The top ranked combinations are presented as blown-up images on the right.

Article Snippet: IC50 values were determined by GraphPad Prism 9 using a 3-parameter dose-response model. Small molecule inhibitors were purchased from Selleckchem: infigratinib (S2183), futibatinib (S8848), pemigatinib (S0088), afatinib (S1011), gefitinib (S1025), EKB-569 (S1392).

Techniques: High Throughput Screening Assay, Inhibition, Amplification, Mutagenesis, Generated, Software